African Walnuts Attenuate Ectopic Fat Accumulation and Associated Peroxidation and Oxidative Stress in Monosodium Glutamate-Obese Wistar Rats

Published on January 2020 | Life Sciences

African Walnuts Attenuate Ectopic Fat Accumulation and Associated Peroxidation and Oxidative Stress in Monosodium Glutamate-Obese Wistar Rats

Authors: Uti, D.E., Atangwho, I.J., Eyong, U.E., Umoru, G.U., Egbung, G.E., Nna, V.U. Udeozor P.A.

View Author: Dr. Daniel Ejim Uti

Journal Name: Biomedicine&Pharmacotherapy

Volume: 124 Issue: 1 Page No: 1-10

Indexing: SCOPUS,Web of Science,Google Scholar,PubMed

DOI URL: https://doi.org/10.1016/j.biopha.2020.109879

328 9 4

Abstract:

Aims: African walnuts were previously shown to modulate hepatic lipid bio-accumulation in obesity. Herein, we investigated the impact of the nuts on fat accumulation in adipose and ectopic regions, and associated oxidation status in obese rats. Materials and methods: Whole ethanol extract (WE) of the nuts, and its liquid-liquid fractions-ethyl acetate (ET) and residue (RES) were separately administered to obese rats for 6 weeks. The normal (NC) and obese (OC) controls received normal saline and the standard control (SC), orlistat (5.14mg/kg b.w.), during the same period. Thereafter, the animals were euthanized and the adipose, brain, kidneys and heart tissues were studied. Results:The change in body weight to naso-anal length which increased by 63.52% in OC compared to NC (p

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