Published on June 2022 | Organic synthesis and spectrscopy

New hydrazones bearing fluoro-benzohydrazide scaffold: synthesis, characterization, molecular docking study, and anti-oxidant investigations

N-Heterocycles are prime Skelton and have been taken as an important contrivance for the construction of competent bioactive molecules. This study intends to amalgamate, characterize, and anti-oxidant assessment of some piperdin-derived (E)-4-fluoro- analogs. We have amalgamated five new piperdin-derived (E)-4-fluoro- compounds. All the designed compounds were characterized using FT-IR, and 1D- NMR. Also, altogether the amalgams were inquired for their anti-oxidant actions in counter to innumerable free radicals. Compounds Z3 and Z4 spectacle outstanding anti-oxidant activities. The results flaunted that the electron-confer (donating) and electron-exodus (withdrawing) sets play a prime role in anti-oxidant actions of the compounds Z (1–5) respectively. A molecular docking study of the compound (Z1) demos that the innumerable ligands of the compound with a glide score value of −4.28 kcal/mol.