Published on February 2022 | Nanotechnology, Nanoparticles, seaweeds, Antidiabetic Activity

In-vivo Anti-Diabetic Efficacy of Silver Nanoparticles from Marine Brown Seaweed Colpomenia sinuosa on Alloxan Stimulated Hyperglycemic Activity in Wistar Albino Rats

Diabetes mellitus is a chronic disease of the endocrine system characterized by elevated blood glucose levels, and disturbances in carbohydrate, fat and protein metabolism. In the present study, the antidiabetic efficacy of biosynthesized silver nanoparticles from marine brown seaweed Colpomenia sinuosa has been evaluated. The anti-diabetic effect of the silver nanoparticles biosynthesized from the Colpomenia sinuosa was assessed by inducing diabetes in the experimental Wistar albino rats through Alloxan monohydrate, a chemical that ultimately results in hyperglycemia (increase in the fasting blood sugar level) at a dosage of 50 mg/kg body weight given orally for about 28 days. The outcome of treatment with silver nanoparticles (50 mg/Kg i.p.) biosynthesized from Colpomenia sinuosa, were estimated using various biochemical parameters. The fasting blood glucose levels have reduced in the affected animals to near-normal levels. The retention of the level of the enzymes involved in diabetes, hematological analysis, decrease in the levels of total cholesterol, triglycerides, low-density lipoprotein, and phospholipids in the silver nanoparticles treated animals compared to the levels in normal control animals, exhibited significant anti-diabetic activity as compared to glipizide.